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Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)

GHK-Biotin also known as Biotinoyl Tripeptide-1 is a biotinylated form of the GHK tripeptide (glycine, histidine, lysine)

However, one of aleglitazar phase 3 trials (NCT01042769) was terminated because of cardiovascular issues

Moreover, GLP-1 receptor agonists seems to be a promising therapeutical agents when it comes to finding new therapies in patients with more aggressive and/or advanced stages of prostate cancer