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337 Although all cell types responded to this inhibitor in vitro and showed promising therapeutic effects in vivo, 337 phase I clinical trials for treating advanced solid tumors ultimately failed due to cardiovascular toxicity and wide variability in patient responses
doi: 10.3389/fonc.2024.1392375 Received 27 February 2024 Accepted 02 April 2024 Published 18 April 2024 Volume 14 - 2024 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Luigi Losco, University of Salerno, Italy Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2024 Crowley, Brown, Gallagher and Dayan
Post-treatment, confocal microscopy analysis revealed enhanced expression of several neurogenic markers: Nestin, GAP43, -tubulin III, and Doublecortin
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