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These conditions include: Kidney disease Liver problems Electrolyte abnormalities Diabetes Low blood volume Overdose A spironolactone overdose can be fatal, but the median lethal dose is extremely high, far greater than the maximum recommended dose of 400 mg per day

The enzyme -glutamyl transpeptidase (GGT), present in the stomach and intestines, rapidly cleaves the tripeptide back into its constituent amino acids before it can ever reach systemic circulation