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He reports resolution of the wearing-off symptoms and an improvement in overnight and early-morning motor symptoms

18 The increased cAMP can further act on protein kinase A (PKA) and guanine nucleotide exchange protein (EPAC), and the activated PKA/EPAC can affect the activated PKA/EPAC can affect the concentration of K + and Ca 2+ ions inside and outside the cell, 19 which in turn promotes insulin secretion