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You are working with your own system rather than around it

Actually, this is not strictly true because there are two relatively small other drains of mass in the methionine cycle, the polyamine drain from SAM and the thiolactone drain from Hcy

At the same time, special stresses, such as inflammation, infections, stimulants and environmental toxins, can also overload our glutathione supplies and lead to glutathione being consumed faster than it is formed