Once absorbed, it triggers several biological actions relevant to skin health: Stimulation of collagen synthesis : Upregulates collagen I and III production Elastin production and glycosaminoglycan support : Promotes sulfated glycosaminoglycan synthesis Matrix regulation : Balances MMPs and TIMPs to maintain connective tissue integrity Growth factor upregulation : Increases growth factors such as VEGF, BDNF, and BMP-2, which are crucial for wound healing and tissue regeneration Antioxidant and anti-inflammatory activity : Demonstrates GHK-Cu's ability to act as an antioxidant and anti-inflammatory agent by neutralizing reactive oxygen species (ROS), modulating inflammatory markers, and protecting skin cells from environmental damage The peptides origin as a collagen fragment released after tissue injury explains its role as a natural signal peptide for repair and tissue remodeling
This dual role, stimulating both synthesis and controlled degradation, is characteristic of wound healing rather than simple collagen accumulation
3-Bromo-1-hydroxy-9,10-anthraquinone (BHAQ) inhibits growth and migration of the human breast cancer cell lines MCF-7 and MDA-MB231
Selank is a synthetic heptapeptide developed by Russian peptide research laboratories as a synthetic analog of the natural tetrapeptide tuftsin, modified with additional amino acid residues to enhance peptide stability and resistance to enzymatic degradation
